1.
Indian J Lepr
;
2000 Jul-Sep; 72(3): 339-50
Article
in English
| IMSEAR
| ID: sea-54262
2.
Indian J Lepr
;
1999 Jan-Mar; 71(1): 69-74
Article
in English
| IMSEAR
| ID: sea-54626
3.
Indian J Lepr
;
1996 Jan-Mar; 68(1): 67-73
Article
in English
| IMSEAR
| ID: sea-54265
4.
Indian J Lepr
;
1995 Oct-Dec; 67(4): 363-74
Article
in English
| IMSEAR
| ID: sea-54232
ABSTRACT
Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion: (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
Subject(s)
Animals , Cyclosporine/pharmacology , Demyelinating Diseases/etiology , Female , Isoantibodies/immunology , Leprosy/microbiology , Mice , Mycobacterium leprae/growth & development , Sciatic Nerve/pathology , T-Lymphocytes/physiology
5.
Article
in English
| IMSEAR
| ID: sea-118994
6.
Indian J Lepr
;
1991 Jul-Dec; 63(3-4): 297-300
Article
in English
| IMSEAR
| ID: sea-54538